The 46-year-old actress, who plays Tristan Wilds' and Shenae Grimes' mom Debbie Wilson on 90210, will be leaving the CW drama at the end of its third season.
"I have enjoyed the past few years working on 90210 and adore all of the cast and crew, as well as the team at the CW and CBS TV Studios," Loughlin recently told E! News. "I am grateful for having had the opportunity to be a part of this wonderful show."
But the Full House alum isn't the only one leaving the famous zip-code later this spring: Ryan Eggold, who plays high school teacher Ryan Matthews, is also reportedly leaving the teen soap.
According to TV Line, the characters were cut in order to focus on the younger cast as they transition to college life in Season 4.Loughlin and Eggold, 26, aren't the first series regulars to leave the show: Rob Estes and Jennie Garth both left after 90210's second season; Dustin Milligan was cut after the first season.